Okay, I’m going to go out on a limb here and guess that because you are reading this, you just might be around my age and are either one of three things:
- Pre-menopausal
- Menopausal
- Post-menopausal
Or, unfortunately, if you have had or are having treatment for some type of hormone-based cancer and the medication blocks the production of estrogen. Regrettably, one of my closest friends is undergoing this type of treatment because she had stage three breast cancer that was hormone-based.
Low estrogen can also affect women in their teens, 20s, and 30s. Non-age-related causes of low estrogen could include eating disorders like anorexia and bulimia or excessive exercise (more than two hours a day).
Either way, you have a lack of estrogen that is affecting your joints, like me. Currently, I am experiencing severe and chronic pain and inflammation in my knees and shoulders. As soon as I can get my insurance squared around, I will be undergoing knee surgery and will require a knee exercise machine. Being pre-menopausal is getting expensive!
How does low estrogen cause joint pain?
The role of estrogen is to protect joints and reduce inflammation. However, if estrogen levels drop to lower levels, inflammation might increase. Additionally, the risk of osteoporosis and osteoarthritis could also go up and painful joints will be the result. And for me, that includes my knees. They are so swollen by the time I go to bed, especially if I have made several trips up and down the stairs; they feel like they are on fire.
According to the National Library of Medicine,“Osteoarthritis (OA) affects all articular tissues and finally leads to joint failure. Although articular tissues have long been considered unresponsive to estrogens or their deficiency, there is now increasing evidence that estrogens influence the activity of joint tissues through complex molecular pathways that act at multiple levels. Indeed, we are only just beginning to understand the effects of estrogen deficiency on articular tissues during OA development and progression, as well as on the association between OA and osteoporosis. Estrogen replacement therapy and current selective estrogen receptor modulators have mixed effectiveness in preserving and/or restoring joint tissue in OA. Thus, a better understanding of how estrogen acts on joints and other tissues in OA will aid the development of specific and safe estrogen ligands as novel therapeutic agents targeting the OA joint as a whole organ,”.
They went on to conclude that, “Different studies have provided compelling information on the relevant effects of estrogen deficiency on joint components in cell culture, animal models or humans. Although much of the attention has focused on the effects of estrogen on articular cartilage, estrogen deficiency also affects other joint tissues during the course of OA, such as the periarticular bone, synovial lining, muscles, ligaments and the capsule,”.
So, what’s a person to do when faced with the grim reality of low estrogen and the accompanying joint pain? First and foremost, an accurate diagnosis from your healthcare provider is needed and will be invaluable. Blood tests reveal hormone levels and help your doctor tailor a treatment plan specifically for you.

In the meantime, there are lifestyle adjustments and treatments that can alleviate some of the pain and inflammation. For starters, anti-inflammatory diets rich in Omega-3 fatty acids, found in fish like salmon, and supplements can make a big difference. Additionally, specific vitamins and minerals such as Vitamin D and Calcium are crucial for bone health and can help counter some of the effects of estrogen deficiency.
Exercise, although it may seem counterintuitive when you’re in pain, can be highly beneficial. Low-impact activities like swimming, walking, and yoga can help keep your joints flexible and reduce stiffness without subjecting them to unnecessary stress. Strengthening the muscles around your joints can also provide better support, minimizing pain and preventing further damage.
In some cases, hormone replacement therapy (HRT) may be considered. This course of treatment can replenish some of the missing estrogen and is shown to alleviate various menopausal symptoms, including joint pain. However, HRT comes with its own set of risks and benefits, so it’s crucial to have a detailed discussion with your doctor about whether it’s the right choice for you.
For those who prefer non-hormonal treatments, other medications can help manage symptoms. Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce swelling and pain, while supplements like glucosamine and chondroitin sulfate are often recommended to support joint health.
Alternative therapies such as acupuncture and physical therapy have also shown promise in managing joint pain. Acupuncture can help manage pain by stimulating specific points in the body, while physical therapy can develop personalized exercise regimens to improve joint function and reduce discomfort.
What does menopause joint pain feel like?
Before doing this research, I used to think that all of my knee pain, joint pain, back pain, shoulder pain cracking and popping all over, and nerve pain was from being a worn-out athlete who never stopped to address her injuries; I am now rethinking some of them at least might be attributed to me being pre-menopausal. And by the way, at the date of this writing, I have not had a menstrual cycle in seven months, so that I might be edging closer to the actual menopause stage.
Healthline shares these common symptoms of low estrogen joint pain women may feel:
- Decreased range of motion
- Cracking or popping sounds when joints move
- Stiffness and swelling in the joints
- Related muscle and back pain
- Shooting pains
It’s important to note that these symptoms can vary significantly from one woman to another. Some may experience mild discomfort, while others could have more severe pain affecting their daily activities. I would recommend consulting with a healthcare professional to explore options for managing and alleviating these symptoms as you transition through this significant phase of life. Taking proactive steps could improve your overall well-being.
Low estrogen knee pain
In conclusion, the path to managing low estrogen knee pain may be winding and challenging, but with the right combination of treatments and lifestyle changes, there is hope for relief. Keep in communication with your healthcare team, stay informed, and don’t hesitate to explore multiple avenues until you find the best strategy for your unique situation. Remember, it’s about crafting a holistic approach that addresses not just the physical symptoms but your overall well-being.
